i did for group content for ages, but when doing dynamic content (missions etc) and raiding, where you have swap targets you have to drive with your tank.
Kiss and the CWTN plugs basically assume (implicitly) that you are driving with your MA
CWTN Plugins aren't under the assumption you drive with the tank.
For the purposes of the plugin you can drive with any toon you want. If for example you want to be a puller to a specified area and have the tank automatically engage you can set the tank into a tank mode, and then just pull thing manually into the camp. The tank would automatically engage the mobs as they entered and then you could assist the tank. It is however the expectation that your MA will likely be your tank, as they should be the first one to engage (aside from puller) which tells other members of the group (using cwtn plugins) that it's time to help.
You can also run a tank in chase assist, but set their assist at to 100 and then set them as the main tank in the group roles which would make them automatically engage anything while chasing that the group has aggro from, as well as do taunting and defensive abilities. This essentially makes it a "chase tank" but without a specific role for the situation being assigned in the plugin.
recently adjustments were made that allow you to use Enchanter/Mage/Necromancer pets as sort of a sudo MA, in that if you set for example a Mage as the MA, and they have a pet, and the pet is engaging a mob inside the camp at melee distance, then it will cause assist toons to assist the mage. It took some adjustments to get that sorted, but it should allow you to set caster classes as MA and expect it to work as it would if you were manually assisting a mage.
Hopefully this clears things up in reference to the CWTN plugins.
With that said. I find it to be infinitely easier to pull and tank with the same toon. There's no need for a transfer of aggro from the puller to the tank, the tank can typically sustain more damage during a pull and reasonably be expected to live, if the tank happens to be an SK they can still split pulls if necessary, etc.
I personally drive with my tank unless I'm testing something else at the moment.