My favorite spot was in Old kurns tower in SOD, using my warrior with the upgraded Honed Wurmslayer, i use this weapon because any mob lower than 85 will not be able to hurt you so only the named in there can hurt you.
There is about 147 mobs if i remember right, and my level 105 warrior could wipe them all out before respawn, then he run down to the start to take care of respawn, there is vendor trash drops, tier 2 spells, some sell on the bazaar but most often its vendor trash, many trade skill items that can be sold on trader, or just outright vendor trash.
I used my old mac pocketfarm to run my warrior, and depending on drop rates and rng, it would make me anywhere from 35k to 53k an hour, this included the time it took me to use another custom mac i had to run through trader and sell the items it could, and then i manually just unloaded everything to a vedor after that mac was done, its not the most profitable i am sure, but i could let it run there a few hours and have a couple grand and be happy
I was always at the keyboard doing things, adjusting loot filters and such till i had a complete loot filter, i use advanced loot with mq2lootmanager to my manage my loot
I would not run there if i saw people in the zone, which i rarely did, but sometimes there be a group come in and spend an hour and get mutilated by the boss and swarm of mobs at the entrance.