To make it perfectly clear what they are saying - MQ2 (MacroQuest2) is the program that makes everything here capable of functioning. It does not work on Truebox servers at all. There is code in it to completely prevent it from functioning on Truebox servers by design.
In fact, your game will completely crash if you try to load a Truebox server with MQ2 loaded. Under no circumstances can anyone here help you get RedGuides up and running on any Truebox server because it literally does not run on Truebox servers. It's not a 'one per computer' issue, it's that MQ2 is totally disabled on Truebox servers.