most of the automated tools tend to confirm that its figthing an npc and not a player, because if you accidently target a player in non pvp, you need it to know not activate all your things, so i would say its a no for most of the tools.
mq2melee does allow changing to allow for attack on players and player pets, but i would never recommend anyone to use mq2melee, and its old and broken in unrepairable ways.