you dont open it, you download install and run mq2 then you run /mac kissassist which creates an ini file for your toon which you can then modify with your spells/discs etc
step 1 download rgupdater
step2 download current mq2compile zip file (inlcudes current Kissassist and other macs)
step 3 run rgupdater, sst path to your zip file and your MQ2 install directory and click update. (this installs all necessary dlls and macs to your selected directory)
step 4 load your toon(s) into game
step5 open your mq2 directory find macroquest.exe and double click to run.
step 6 type /mac kissassist the the mq2window. once its opened and closed block spell windows type /end
step 7 goto your mq2/macros folder find the kissassist.name.server.ini file for your toon, open it in notepad or such and edit it to suit your needs and bobs your uncle your all set to rock