Your computer far exceeds mine, and i have no problems running 6 clients, what you need is mq2eqwire and optimize your eqclient.ini
I run 6 clients, chrome, vlc watching a movie, while i chat on discord and use vscode to edit inis and macros, and sometimes i even load meshgen and regen a mesh or fix it on the fly(now this my computer dont like)
wineq2s only bonus is the fullscreen windowed mode, but that's for the paid version, the other features are not really needed anymore, or is already implemented in mq2 or eq itself.
i forget if the custom eqclient.ini pr client is for paid or free version but thats okay feature but we can allready do that without.