Assuming you're asking about with kissassist? You didn't specify - but yes absolutely you can, and its pretty easy once you know how.
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You can /addignore a mob - and you can either provide a name like "
/addignore skeleton" which would ignore anything with skeleton in their name - or you can do something like
/addignore ${Target.CleanName} which would add your target to the addignore
This information is stored in your KissAssist_Info.ini in your macro folder
| /addignore |
KissAssist_Info |
Adds [text] to the MobsToIgnore list - accepts partial names and checks against ${Spawn} |