I'm *very* new to this. When Vanilla MQ2 is active the 1 key (on the row, not the numpad), doesn't appear to do anything in-game (though it might be doing stuff I don't realize) and will not even put the character 1 into a chatbox, but when I'm tabbed out pressing that key immediate returns me to the Everquest window. It didn't do that yesterday, but does today...
Closing MQ2 fixes the problem.
Closing MQ2 fixes the problem.