This is how it could work. This is only an example of 1 way to do this. This example also assumes you have various plugins loaded, like MQ2Map, etc..
After you have started Kissassist on your puller/puller tank. You open up your map right click on the mob(Target mob) you want to ignore. Click on a social key that is defined to trigger an event that adds the targets ID to a list. Now in kissassist where the refresh, than Maskoi is referring to, is being executed. At the very end you could add the list of ID's to the alert list and bam all the targets you want to ignore will be ignored.
There are other methods that could be used to determine what mobs to ignore, but I would want to do it manually why others would want some automatic way of doing it. but none of them would adhere to the K.I.S.S. standards.