It all depends on which macro you're referencing.
If you're talking about Kissassist INI's then the pre-made INI's are player made and generally are created in 5 level increments. But all of the INI's are expecting you to verify you have all the abilities available to you and match what you'd like them to do and when.
RGMercs isn't level specific, and should work at any of those levels.