Agree. I have a n52 and really don't like playing without it. Prior to many of the EQ upgrades (melody, autofire) I use to use it for those functions. Now I use it as a better way than the keyboard. Since it holds 4 shift sets, I have the first set to my hotkey bank 1, second to hotkey 2, etc. That leaves 4 more keys, the wheel, tophat, and the big orange button.
BOB set to attack,
bottom 4 keys for things I do all the time while pulling (like "U" to open doors),
tophat = NPC cycle, PC cycle, Target self, and one to my Ventrilo PTT.
wheel = just set like my mouse so I can pan back from there too.
But then I normally play using either the mouse movement, or num-pad for movement, so this lets me click things faster on screen while I'm still scooting somewhere.