Plugins generally have less impact then macros, as I understand it.
And while they can add up, I understand it is a small impact, depending of course on what the plugin is doing.
If you suspect plugin may be causing you an issue, the easiest thing to do is unload all but the ones essential for what you are doing (keep MQ2IC, thats the "can't see me" one that hides MQ from DBG) and then load 1 plugin at a time back to where you were 9with extended play time in between) that way you can narrow down the one that is causing you an issue.