It's easy to 3 box without 3rd party software.
It's even possible to 6 box and more without 3rd party software. I got myself up to 6 boxing.
I would recommend mastering up to 6 boxing without 3rd party software first.
It will give you a better understanding on they dynamics of multi-boxing, esp on things like creating social macros, and just generally juggling multiple toons at once.
I don't use MQ myself, but this is still the best website for learning how to multibox, regardless if you use 3rd party software or not.
I only learned about this website a few days ago. Apparently it's banned on ths everquest reddit, since it does talk about MQ.
First of all, mad respect to your boxing skills!
However, I am going to disagree a bit on "its easy" to 3 box without 3rd party software. At least for me! I may be exceptionally sucky (most likely) but I used to Duo Box a Monk and a Shammy back before I even knew what MQ was and it was HARD af! It took me a long time to get all the hotkeys and shortcuts set to be even reasonably effective in bad situations and still when things got super sporty it was very hard for me. Also worthy of note, this was before Mercs as well. I do recognize a crew with mercs would be easier.
But, I think "easy" might not apply to everyone. Especially not SIX boxing without MQ. Is it doable? Yes, absolutely, by skilled folks with alot of time on their hands. Is it "easy"? In my opinion, (as a sucky player), it isn't easy.
Using MQ literally changed the entire game for me. There is no way I would still be playing EQ after 20 years without MQ. I six box my own crew and do any group content I want without ever LFG. So for me, "cheating" with MQ is more than worth it.
For the OP, if you want to play without MQ just to learn more about the base game and playing each class, great. But, in my humble opinion, nothing beats boxing with MQ and the top of that chain is boxing with CWTN plugins leading the crew with your Tank.
Again, I am a sucky player, but there is just no way on earth I could box any of these complex missions with specific mechanics in different phases of the mission without MQ.